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Start-stop System of Hunting Immune Cells How immune cells coordinate their swarming behaviour to effectively eliminate pathogens: A publication in "Science" presents new findings. WüSI scientist now show how these cells turn into effector cells… Learn more Hobit Turns Immune Cells Into Killers ILCs are rapid reaction forces that reside in tissues to combat infections and tumors. A research team at the University of Würzburg has now deciphered new details of these processes. How sugar promotes inflammation Excessive sugar consumption can promote inflammatory processes in the body and facilitate the development of autoimmune diseases. Researchers have discovered an essential role of these cells in the treatment of cancer and severe viral infections. Why Sentinel Cells are so Important The presence of sentinel immune cells is vital to maintain and regulate the balance of the body’s immune response. Research teams from Würzburg and Freiburg have now discovered an approach that could be used to slow down this process. In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors, Immunity, 2020Ī human liver cell atlas reveals heterogeneity and epithelial progenitors, Nature, 2019Ī potential fountain of youth for the immune system In old age, the performance of the immune system decreases, and older people are more susceptible to infections. Neutrophils self-limit swarming to contain bacterial growth in vivo, Science, 2021īATF3 programs CD8+ T cell memory, Nature Immunology, 2020 Group 1 ILCs regulate T-cell-mediated liver immunopathology by controlling local IL-2 availability, Science Immunology, 2022Įffector differentiation downstream of lineage commitment in ILC1 is driven by Hobit across tissues, Nature Immunology, 2021 open accessĬhemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration, Nature Cell Biology, 2021 The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming, Cell Metabolism, 2022 Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches, Immunity, 2022 The goal is to understand the basic principles for a successful immune response against infectious agents and tumors and to use them therapeutically.ĭevelopmental dynamics of two bipotent thymic epithelial progenitor type, Nature, 2022
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Our research group is developing new genetic tools that allow us to visualise a wide variety of specific cell types and to test their function. Using intravital multiphoton microscopy, we were recently able to clarify the early cellular events during the adaptive immune response to a virus infection. These "local defense forces" also play a role in the regeneration of organs or the regulation of metabolic processes, for example. The group is also investigating lymphocytes that permanently settle in different tissues and specialise in the requirements of their environment.
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We investigate the migration of leukocytes between and within organs, and investigate where and how cells of the immune system interact to achieve an effective immune response or to prevent inflammatory disease processes. The Max Planck Research Group investigates the interaction of the immune system with the organism, in particular the interaction of different cells of the immune system in local networks and with cells of other organ systems.